Education

09/1993 - 12/1997:      Ph.D., Department of Cell Biology, University of Alabama at Birmingham, USA

09/1985 - 07/1991:       M.D., Peking University Health Science Center (formerly Beijing Medical University), Beijing, China

Employment / Experience

01/2008 – present:  Associate Professor (secondary appointment), Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine.

07/2007 – present:  Associate Professor with Tenure, Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh.

10/2006- present:    Associate Director, Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy.

08/2005- 09/2005:  Interim Director, Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy.

2004 – present:       Member, Center for the Environmental Basis of Human Disease (CEBHD), University of Pittsburgh School of Public Health.

2003 – 2007:          Assistant Professor (secondary appointment), Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine.

2002 – present:       Member, Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute.

2002 – present:       Faculty Member, Molecular Pharmacology Training Program, Department of Pharmacology, University of Pittsburgh School of Medicine.

04/2002 – 06/2007: Assistant Professor, Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh.

04/1998 – 03/2002: Postdoctoral Research Fellow with Dr. Ronald M. Evans, Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, USA.     

01/1998 - 03/1998: Postdoctoral Research Fellow with Dr. Jeffrey E. Kudlow, Department of Cell Biology and Medicine, University of Alabama at Birmingham, USA.

09/1994 - 12/1997: Graduate Research Assistant with Dr. Jeffrey E. Kudlow, Department of Cell Biology/Medicine, University of Alabama at Birmingham, USA. 

09/1993 - 08/1994: Graduate Research Assistant with Dr. Richard Mayne, Department of Cell Biology, University of Alabama at Birmingham, USA       

08/1991 - 08/1993: Research Associate with Dr. Jidi Chen, Division of Biochemistry, Institute of Sports Medicine, Beijing Medical University, Beijing, China.                 

Selected publication ( more than 70 papers)

1.          Gong H, Jarzynka MJ, Cole TJ, Lee JH, Wada T, Zhang B, Gao J, Song WC, DeFranco DB, Cheng SY, Xie W.  Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase.  Cancer Research 68: 7386-7393 (2008)

2.          Uppal H, Zhai Y, Gangopadhyay A, Khadem S, Ren S, Moser JA, and Xie W. Activation of LXR sensitizes mice to gallbladder cholesterol crystallization. Hepatology 47: 1331-1342 (2008)

3.          Zhou J, Liu M, Zhai Y, and Xie W. The anti-apoptotic role of pregnane X receptor in human colon cancer cells. Molecular Endocrinology 22: 868-880 (2008)

4.          Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, Khadem S, He J, Lee JH, Ren S, Li S, Silverstein RL, and Xie W. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR and PPARg in promoting steatosis. Gastroenterology 134: 556-567 (2008)

5.          Sáenz-Robles MT, Toma D, Cantalupo P, Zhou J, Gong H, Edwards C, Pipas JM, and Xie W.  Repression of intestinal drug metabolizing enzymes by the SV40 large T antigen. Oncogene 26: 5124-5131, 2007

6.          Xie W, and Tian Y. Xenobiotic receptor meets NF-kB, a collision in the small bowel.  Cell Metabolism 4: 177-178 (2006).

7.          Xie W, Yeuh M-F, Radominska-Pandya A, Saini SPS, Nigishi Y, Bottroff BS, Cabrera GY, Tukey RH, and Evans RM. Control of steroid, heme and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.  Proc. Natl. Acad. Sci. USA. 100: 4150-4155 (2003).

8.          Xie W, Barwick JL, Simon CM, Pierce A, Safe S, Blumberg B, Guzelian PS, and Evans RM.  Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.  Genes & Development 14: 3014-3023 (2000).

9.          Xie W, Barwick JL, Simon CM, Downes M, Blumberg B, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, and Evans RM.  Humanized xenobiotic response in mice expressing nuclear receptor SXR.  Nature 406: 435-439 (2000).

10.      Xie W, Chow LT, Paterson AJ, Chin E, and Kudlow JE.  Conditional expression of erbB2 oncogene in transgenic mice elicits striking hyperplasia in stratified epithelia, and up-regulation of TGFa expression. Oncogene 18: 3593-3607 (1999).

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