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代谢相关基因的功能研究

生理与病理生理学系及糖尿病中心学术活动

题目:代谢相关基因的功能研究

讲演人:常永生, Ph.D.

                      副研究员

                      医科院基础所

                      医学分子生物学国家重点实验室

时间:2008-11-20(周四),12:00

地点:生理楼三层会议室

 

常永生,男,副研究员,中国医学科学院基础医学研究所,2002年毕业于中国协和医科大学,获得Ph.D;2002年到2006年在National Jewish Medical and Research Center, Denver, CO, USA从事KGF signaling pathway and lipogenesis研究;2006年回国后,在医科院基础所生化系医学分子生物学国家重点实验室工作,现主要从事:①、2型糖尿病相关的microRNA鉴定及功能研究;②、代谢相关基因FOXO1, PGC-1等蛋白质翻译后修饰对其功能的影响。曾获中华医学科技奖一等奖(2001)和Della McShane Fellowship (2003)。已发表了SCI论文20余篇。   所在实验室代表性的文章: Liu L, et al. Proteomics-based identification of the differentially expressed plasma proteins including galectin-1 in type 2 diabetic patients. Journal of Proteome Research. (accepted) Liu L, et al. Protein kinase Cζregulation of Glut4 transloction through actin remodeling in CHO cells. Journal of Molecular Medicine.2007,volume 85, issue 8, p851-861 He A, et al. Over-expression of miR-29, highly upregulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocyte, Molecular Endocrinology, 2007 , volume 21, issue 11, p2785-2794  Liu L, et al. Protein kinase Cζmediates insulin-induced glucose transport through actin remodeling in L6 muscle cells. 2006, Molecular Biology of the Cell, volume 17, Issue 5, p2322-2330  Zhao J,  et al. An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese. Journal of Molecular Medicine, 2006, volume 83, issue 3, p209-215 Feng Q, et al. Two domains are critical for the nuclear localization of soluble adenylyl cyclase. 2006, Biochimie, volume 88, issue 3-4, p319-328

 

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