学术信息
In search of islet growth factors: from IGF-I to Reg proteins
生理与病理生理学系及糖尿病中心学术活动
题目：In search of islet growth factors: from IGF-I to Reg proteins
讲演人：Jun-Li Liu, PhD
Associate Professor
Department of Medicine
McGill University
时间：2007-6-27（Friday），11:30am
地点：生理楼三层会议室
CV of Jun-Li Liu Education 1978-1982, Peking University 1982-1985, MS, Physiology, Peking University, Health Science Centre, 1990-1995, PhD, Experimental Medicine, McGill University, Montreal, Canada 1995-2000, Postdoctoral, Endocrinology, National Institutes of Health, NIDDK, Bethesda Positions and employment 1985-1989, Lecturer, Department of Physiology, Peking University Health Science Centre 2000-2008, Assistant Professor, Department of Medicine, McGill University, Montreal, Canada 2008- Associate Professor, Department of Medicine, McGill University, Montreal, Canada 2000- Medical Scientist, McGill University Health Centre, Montreal, Canada 2003- Member, Montreal Diabetes Research Centre, Montreal, Canada Selected publications:
1. K Robertson, Y Lu, B Li, Q Su, PK Lund and JL Liu. A general and islet cell-enriched overexpression of IGF-I results in normal islet cell growth, hypoglycemia and significant resistance to experimental diabetes. Amer J Physiol-Endo Metab 2008; 294: E928-38
2. K Robertson, JJ Kopchick and JL Liu. Growth hormone receptor deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice. Amer J Physiol -Endo Metab 2006; 291: E491-498
3. Y Lu, A Ponton, H Okamoto, S Takasawa, PL Herrera, and JL Liu. Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas. Amer J Physiol -Endo Metab 2006; 291: E50-58
4. Y Guo, Y Lu, D Houle, K Robertson, Z Tang, JJ Kopchick, YL Liu and JL Liu. Pancreatic islet-specific expression of an IGF-I transgene compensates islet cell growth in growth hormone receptor gene deficient mice. Endocrinology 2005; 146: 2602–2609
5. R Yu, S Yakar, YL Liu, Y Lu, D LeRoith, D Miao, and JL Liu. Liver-specific IGF-I gene deficient mice exhibit accelerated diabetes in response to streptozotocin, associated with early onset of insulin resistance. Mol Cell Endocrinol 2003; 204: 31-42 热忱欢迎参加！