学术信息
Metalloproteinases in unstable atherosclerosis
发布日期：2007-12-05
生理与病理生理学系及糖尿病中心学术活动
题目：Metalloproteinases in unstable atherosclerosis
讲演人：Newby, Andrew Christopher， Ph.D.
Universtity of Bristol
Bristol Heart Institute
时间：2007-12-10（Monday）, 11:30am
地点：生理楼三层会议室
Professor Newby, Andrew Christopher, from University of Bristol, British Heart Foundation Professor of Vascular Cell Biology from October 1995, Co-director of the EC-funded European Vascular Genomics Network (2004-2008), Chairman of the Council on Basic Cardiovascular Science of the European Society of Cardiology (2004-2006). His research interest is: Cell and molecular biology of vascular cells, in particular control of vascular smooth muscle proliferation in atherosclerosis formation and restenosis after angioplasty. Selected Publications: ( among 45 reviews and 130 papers) Luan Z, Chase AJ, Newby AC (2003). Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophages. Arterioscler Thromb Vasc Biol. 23:769-775. Bond M, Sala-Newby GB, Newby AC (2004). Focal adhesion kinase (FAK)-dependent regulation S-phase kinase associated protein-2 (Skp-2) stability: A novel mechanism regulating smooth muscle cell proliferation. J Biol Chem. 279:37304 - 37310. Wu Y-J, Bond M, Sala-Newby GB, Newby AC (2006). Altered S-Phase kinase-associated protein-2 levels are a major mediator of cyclic nucleotide-induced inhibition of vascular smooth muscle cell proliferation. Circ Res. 98:1141-1150. Thomas AC, Sala-Newby GB, Ismail Y, Johnson JL, Pasterkamp G, Newby AC (2007). Genomics of Foam Cells and Nonfoamy Macrophages From Rabbits Identifies Arginase-I as a Differential Regulator of Nitric Oxide Production. Arterioscler Thromb Vasc Biol. 27:571-577. Murphy GJ, Johnson TW, Chamberlain MH, Rizvi SI, Wyatt M, George SJ, Angelini GD, Karsch KR, Oberhoff M, Newby AC (2007). Short- and long-term effects of cytochalasin D, paclitaxel and rapamycin on wall thickening in experimental porcine vein grafts. Cardiovasc Res. 73:607-617.
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