主讲人：Jian-Ying Wang, M.D., Ph.D.

Professor of Surgery and Pathology

Associate Chair for Basic Research

Department of Surgery

University of Maryland School of Medicine

 

时  间： 07年3月14日 （星期三）上午11:00

地  点：生理楼三层会议室

        

欢迎参加。

 

 

Jian-Ying Wang, M.D., Ph.D.

 

Studies in Dr Wang’s laboratory are to define biological functions of cellular polyamines, especially roles of polyamines in regulation of gut epithelial cell renewal, migration, apoptosis, and cell-cell interactions. Roles of polyamines in regulation of expression of growth-related genes such as proto-oncogenes (c-myc and c-jun) and tumor suppressor genes (p53, junD, and NPM) are investigated in vivo and in vitro systems. They have recently focused on studies to define the role of RNA-binding proteins such as HuR in regulation of p53 and NPM mRNA stability following polyamine depletion. Their studies also elucidate the process by which polyamines modulate intracellular Ca2+ homeostasis, particularly involvement of Kv channels and TRPC channels in this process. 

 

Recent publications including:

 

1.                     Liu L, Li L, Rao JN, Zou TT, Zhang HM, Boneva D, Bernard MS, and Wang J-Y.  Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation.  Am J Physiol Cell Physiol 288:C89-C99, 2005.

2.                     Guo X, Rao JN, Liu L, Zou TT, Keledjian KM, Boneva D, Bernard MS, and Wang J-Y.  Polyamines are necessary for synthesis and stability of occludin in intestinal epithelial cells.  Am J Physiol Gastrointest Liver Physiol; 288: G1159-G1169, 2005.

3.                     Zou T, Rao JN, Liu L, Marasa BS, Keledjian KM, Zhang AH, Xiao L, Bass BL, and Wang J-Y.  Polyamine depletion induces NPM modulating stability and transcriptional activity of p 53 in intestinal epithelial cells.  Am J Physiol Cell Physiol 289:C686-C696, 2005.

4.                     Rao JN, Platoshyn O, Golovina VA, Liu L, Zou T, Golovina VA, Marasa BS, Turner DJ, Yuan J X-J, and Wang J-Y.  TRPC1 functions as store-operated Ca2+ channels in intestinal epithelial cells and regulates early mucosal restitution after wounding.  Am J Physiol GI and Liver Physiol Published online (November 10, 2005), dio10.1152/ajpgi.00441.2005.

5.                     Zhang HF, Keledjian KM, Rao JN, Zou T, Liu L, Marasa BS, Strauch ED, and Wang J-Y.  Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kB signaling in intestinal epithelial cells. Am J Physiol Cell Physiol (December 14, 2005), doi:10.1152/ajpcell.00450.2005