主讲人：徐国恒  教授            北大医学部生理与病生理学系教授   时  间：06年11月16日（星期四）11：30am   地  点：生理楼三层会议室   主  办：北大医学部生理与病生理学系                  欢迎参加。       徐国恒 教授: 生理与病生理学系肥胖与代谢研究室PI，主要研究方向为：脂肪分解和脂肪酸运动的分子调控机制以及肥胖、胰岛素抵抗、泡沫细胞形成的细胞生物学机制。2004年入选教育部新世纪优秀人才支持计划，获得专项资助，现承担多项国家级课题，近两年部分性代表论文包括： 1.                     Hongfeng Jiang, Chaoshu Tang, Jinhan He, Guoheng Xu*. Heat shock protein 70 translocates to the lipid droplet surface in adipocytes upon heat shock stress. Biochimica et Biophysica Acta – Lipid,  revised 2.                     Tingting Ren, Jinhan He, Hongfeng Jiang, Luxia Zu, Shenshen Pu, Xiaohui Guo*, and Guoheng Xu*. Metformin blocks lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-a or isoproterenol.  Journal of Molecular Endocrinology. 2006, 37(1); 175-183. 3.                     Jinhan He, Hongfeng Jiang, John T. Tansey, Chaoshu Tang, Shenshen Pu, and Guoheng Xu*. Calyculin and Okadaic Acid Promote Perilipin Phosphorylation and Increase Lipolysis in Primary Rat Adipocytes.  Biochimica et Biophysica Acta -Mol Cell Biol of Lipid.  2006; 1761(2): 247-255. 4.                     Xu G * , Sztalryd C, Kimmel AR, and Londos C. Degradation of perilipin is mediated through ubiquitination-proteasome pathway.   Biochimica et Biophysica Acta - Mol Cell Biol of Lipid. 2006; 1761(1): 83-90. 5.                     Xu G, Sztalryd C, Lu X, Dorward H, Tansey JT, Kimmel AR, and Londos C. Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway.   Journal of Biological Chemistry. 2005; 280(52):42841-7. 6.                     Zhang M, Wang X, Zhang D, Xu G, Dong H, Yu Y, Han J. Orphanin FQ antagonizes the inhibition of Ca(2+) currents induced by micro-opioid receptors.  Journal of Molecular Neuroscience. 2005;25(1):21-7