生理学与病理生理学系及北大糖尿病中心学术活动通知

题目：Oxidative Protein Modifications in Vascular Complications in Diabetes

讲演人： 邹明辉教授 ,  理学博士, 自然科学博士

美国俄克拉荷马大学医学院医学细胞生物学生理学系 终身教授 ，Travis特聘讲座教授; 美国俄克拉荷马大学医学院医学系血管生物学研究主任

时间：4.3日中午12点整

地点：生理楼三楼会议室

 

申请者近年的主要论著目录

1. * Zhang M., Dong, Y., Xu, J., Xie, Z., Wu, Y., Song, P., Guzman, M., and Zou, M-H. Thromboxane receptor via hydrogen peroxide activates the AMP-activated kinase in vascular smooth muscle cells. Circ Res 102:328-337, 2008

2. * Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH. Phosphorylation of LKB1 at serine 428 by protein kinase C-z is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. Circulation 117:952-962, 2008

3. * Song, P., Wu, Y., Xu, J., Xie, Z., Dong, Y., Zhang, M., and Zou, M.H. Reactive Nitrogen Species Caused by Hyperglycemia Suppresses Protein Kinase B/Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN in an LKB1-dependent Manner.  Circulation 116;1585-1595; 2007

4. * Xu, J., Wu, Y., Song, P., Zhang, M., Zou, M.H. Proteasome-dependent degradation of GTP-cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes. Circulation. 116(8):944-53, 2007.

5. *Davis, B. and Zou, M.H. CD40Ligand (CD 40L )-dependent tyrosine nitration of prostacyclin synthase in vivo. Circulation. 112(14):2184-92, 2005.

6. Dong, Y., Wu, Y., Wu, M., Wang, S., Zhang, Y., Xie, Z., Xu, J., Song, P., Wilson, K., Zhao, Z., Lyons, T., Zou, M.H. Activation of the Calcium-Dependent ?-Calpain by Oxidized and Glycated LDL Triggers the Degradation of Endothelial Nitric Oxide Synthase. J. Cell. Mol. Med. In press.

7. Xie, Z., Song, P., Zhang, M., Zou, M.H. Up-regulation of Mitochondrial Uncoupling Protein-2 by the AMP-activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes. Diabetes. 57(12):3222-30, 2008.

8. Zhang, J., Xie, Z., Wang, S., Zou, M.H. Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Endothelial Cells. J. Biol. Chem. 283(41):27452-61, 2008.

9. Zhang S, Wang J, Dashti A, Wilson K, Szweda L, Zou, M. H, Lyons T, Ma JX. Pigment epithelium-derived factor (PEDF) mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized-LDL. J Mol. Endocrinol. 41(3):135-43, 2008.

10. Wang, S., Xu, J., Song, P., Wu, Y., Zou, M.H. Gene Silencing of GTP cyclohydrolase 1 by small RNA interference uncouples endothelial nitric oxide synthase in vivo. Hypertension. 52(3):484-90, 2008

11. Choi HC, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, Zou MH. Protein Kinase C-z Dependent Serine 428 Phosphorylation and Nuclear Export of LKB1 Is Required for Statins-induced Activation of the AMP-activated Kinase. J. Biol. Chem. 283(29):20186-97, 2008

12. Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH. Protein kinase C ζ-dependent LKB1 phosphorylation at Ser428 induced LKB1 nuclear export and apoptosis in endothelial cells. J. Biol. Chem. 283(18):12446-55, 2008

13. Wenzel, P., Daiber, A., Oelze, M., Brandt, M., Closs, A., Xu, J., Thum, T., Bauersachs, J., Ertl, G., Zou, M.H., F?rstermann, U., Münzel, T. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus.  Atherosclerosis 198(1):65-76, 2008

14. Wu, Y. and Zou, M.H. Activation of the AMP-activated kinase as a strategy of protecting endothelial function. Clinical and Experimental Pharmacology and Physiology. 35, 535–545, 2008

15. Zou, M.H. DNA hypomethylation and endothelial degeneration in hyperhomocysteinemia. Blood. 100:3495-3496, 2007