yl9193永利院长论坛系列

　　报告题目：IKK/NFkB p50/GADD45Α: A Novel Apoptotic Pathway Upon Arsenite Exposure

　　报告人：Chuanshu Huang, M.D., Ph.D.

　　时    间：2009年6月23日（星期二）下午2：00

　　地    点：医学部会议中心205室

　　主持人：周春燕教授（yl9193永利生物化学与分子生物学系教授）

　　报告人简介：

　　Professor and Deputy Director

　　Nelson Institute of Environmental medicine

　　Director, Program of Chemoprevention of NYU cancer Institute

　　New York University School of Medicine

　　Abstract
        The crosstalk between NFκB and JNKs has been implicated in the cell life and death decision. Functional suppression of JNKs activation by NFκB has been recently proposed as a key cellular survival mechanism. Here, we provide a novel scenario of the pro-apoptotic role of IKK/NFκB p50/GADD45α, which can act as the activator of the MKK4/JNKs pathway in response to the stimulation of a cytotoxic reagent arsenite. This effect appears to be dependent on p50, and not p65/relA NF-κB subunit. This GADD45α up-regulation depended on NFκB p50-mediated its de-ubiquitination and proteasomal degradation, rather than by NFκB transcriptional activity. As NF-κB and JNKs are implicated in cancer development and are activated simultaneously by numerous stimuli, our findings are important for the development of the rationale design of targeting NF-κB for medical purposes.

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