主讲人：王文恭  教授            北大医学部生物化学与分子生物学系教授   时  间： 06年11月10日（星期五）  上午 11：30   地  点：生理楼三层会议室   主  办：生理及病生理学系                欢迎参加。

王文恭：

北京大学医学部生物化学与分子生物学系教授，北京大学衰老研究中心副主任，博士生导师。近两年部分代表性论文包括：

1.                    Wang, W., Yang, X., Lopez, I., Carking, D., and Gorospe, M.: In creased AMP:ATP Ratio and AMP-activated Protein Kinase Activity during Cellular Senescence Linked to Reduced HuR Function.  J. Biol. Chem., 278(29): 27016-27023, 2003 2.                    Galban, S., Martindale, J., Fan, J., Lopez, I., Mazan-Mamczarz, K., Wang, W., Decker, J., and Gorospe, M.: Influence of RNA-Binding Protein HuR in pVHL-Regulated p53 Expression in Renal Carcinoma Cells.  Mol. Cel. Biol., 23 (20): 7083-7095, 2003 . 3.                    Yang, X., Wang, W., Fan, J., Lal, A., Yang, D., Cheng, H., and Gorospe, M.: Prostaglandin A2-mediated Stabilization of p21 mRNA through an ERK-dependent Pathway Requiring RNA-binding Protein HuR.  J. Biol. Chem., 279(47): 49298-306, 2004 4.                    Wang, W *., Yang, X., Kawai, T., Lopez De Silanes, I., Mazan-Mamczarz, K., Chen, P., Chook, Y., Quensel, C., Kohler, M., Gorospe, M.: AMPK-Regulated Acetylation and Phosphorylation of Importin-a1: Involvement in the Nuclear Import of RNA-binding Protein HuR.  J. Biol. Chem., 279(46): 48376-88, 2004. * Correspondence Author. 5.                    Wang, W., Yang, X., Martindale, J., and Gorospe, M.: AUF1-Mediated mRNA Turnover is Responsible for Up-regulation of p16 during Replicative Senescence.  EMBO Rep., 6 (2): 158-164, 2005.