CV of Hongying Wang

Education

1995      MD.    Zhejiang University Medical School, Zhejiang, PR. China (Medicine)

2000   Ph.D.     Department of Pharmacology (Dr. Chi-Hin Cho), University of Hong Kong, Hong Kong , PR China (Gastrointestinal Pharmacology)

Positions and employment

1994-1995     Internship (Medicine)

The First Affiliated Hospital of Zhejiang University Medical School, Hangzhou, Zhejiang, PR China

1995-1997     Residency (Internal Medicine)    

Department of Internal Medicine, Wutan Hospital, Xushui, Hebei , PR China

2000-2002     Postdoctoral Fellowship

Department of Molecular and Cellular Oncology (Dr. Mien-Chie Hung), MD Anderson Cancer Center, University of Texas at Houston, Texas, USA

Projects involved:

1).    Anti-tumor effect of PEA3 in breast cancer

2).    Clone interferon-induced antitumor gene, AIM2

3).    Interaction of b-catenin and NF-kB pathways

2002-2008   Postdoctoral Fellowship (CAG/CIHR fellowship)

Department of Physiology and Biophysics (Dr. Wallace K MacNaughton), University of Calgary, Calgary, Alberta, Canada

Projects involved:

1).   b-catenin blocks NO-induced apoptosis in colon cancer cells

2).   b-catenin mediates PAR-induced cyclooxygenase-2 expression

3).   Nitric oxide induces Wnt-induced secreted protein-1 expression in colon

4).   PARs induce IL-8 expression in colon cells

5).   Role of NO-induced b-catenin degradation in inflammation-related barrier dysfunction

6).   Role of b-catenin in PAR-induced cell proliferation

2008 June-     Research Assistant Professor

Department of Physiology and Biophysics

University of Calgary, Calgary, Alberta, Canada

Selected publications:

1.              Wang H, Ma L, Li Y and Cho CH.   The role of nitric oxide on the cigarette smoke-induced programmed cell death in the gastric mucosa. Scand J Gastroenterol 36:235-240, 2001.

2.              Wang H, MacNaughton WK.  Overexpressed b-catenin blocks nitric oxide-induced apoptosis in colonic cancer cells.  Cancer Research 65:8604-8607, 2005.

3.              Wang H, Wen SB, Bunnett NW, Leduc R, Hollenberg MD and MacNaughton WK. Proteinase-activated receptor 2 (PAR2) induces cyclooxygenase-2 expression through b-catenin and CREB.  Journal of Biological Chemistry 283:809-815, 2008.

4.              Nguyen H, Wang H, Le T, Ho W, Sharkey KA, Swain MG. Downregulated hypothalamic 5-HT(3) receptor expression and enhanced 5-HT(3) receptor antagonist-mediated improvement in fatigue-like behaviour in cholestatic rats.  Neurogastroenterol Motil 20:228-35, 2008.

5.              Wang H, Zhang R, McCafferty DM, Beck PL and MacNaughton WK. Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1) in colitis. (Revised by Journal of Clinical Investigation)