学术信息
【院长论坛】Personalized cancer medicine through a systems biology approach
yl9193永利
院长论坛
报告题目:Personalized cancer medicine through a systems biology approach
报告人:Edwin Wang
National Research Council Canada,
Biotechnology Research Institute,Montreal
时间:2010年10月28日(星期四)下午2:00
地点:医学部逸夫教学楼509教室
主持人:尹玉新教授
报告简介:
Recent studies have determined that many drugs work well for less than half of the patients for whom they are prescribed. Furthermore, nearly 3 million incorrect or ineffective prescriptions are written annually and more than 100,000 people in the U.S. die each year from drug-related adverse events. These data strongly suggest that one-size-fits-all medicine and preventive care are not effective. Moreover, effective treatment of disease requires considering the effects of the patient’s personal genetic background. Large-scale sequencing and omic profili
ng of cancer genomes have generated huge amount of data. The continual development of faster and cheaper DNA sequencing and other high-throughput technologies will lead to generating data in a routine clinical manner. Thus, it is possible to adopt a systems biology strategy for getting insights from these data for medical research and finally moving forward into the era of personalized medicine.
I will discuss how to make sense of and make use of these data to conduct network modeling and biomarkers for personalized cancer patient care: (1) drug response and prognosis marker discovery from the omic data; (2) cancer patient-based gene network reconstruction and modeling to understand the cancer progression and metastasis such EMT-network modeling; (3) network analysis for drug targets for cancer drug resistance.