生理学与病理生理学系及北大糖尿病中心学术活动通知

题目：Mechanotransduction and Mechanobiology in Health and Diseases

讲演人：裘正健 教授

        台湾国立卫生研究院医学工程研究组研究员

        台湾国立扬名阳明大学医学工程研究所合聘教授

        台湾国防医学院生命科学研究所兼任教授

时间：3.11日下午4点整

地点：生理楼三楼会议室

 

近年代表性论文：

n             Chiu JJ, Chien S. Role of disturbed flow in vascular endothelial biology and pathophysiology. Physiological Review. (Invited; To be submitted), 2008.

n             Chang SF, Chang DK, Peng HH, Lee DY, Yeh CR, Cheng CK, Chang AC, Chiu JJ*. Bone morphogenetic protein-4-induced cell cycle arrest and differentiation are regulated by b3 integrin and Smad-mediated p21CIP1 and p27KIP 1 in osteoblast-like Cells. Journal of Bone and Mineral Research. In revision, 2008.

n             Chiu JJ, Usami S, Chien S. Vascular endothelial responses to altered shear stress. Annals of Medicine. 18:1-10, 2008.

n             Lee DY, Yeh CR, Chang SF, Lee PL, Chien S, Cheng CK, Chiu JJ*. Integrin-mediated expression of bone formation-related genes in osteoblast-like cells in response to fluid shear stress: roles of extracellular matrix, Shc, and mitogen-activated protein kinase. Journal of Bone and Mineral Research. 23:1140-9, 2008.

n             Chang SF, Chang CA, Lee DY, Lee PL, Yeh YM, Yeh CR, Cheng CK, Chien S*, Chiu JJ*. Tumor cell cycle arrest induced by shear stress: roles of integrins and Smad. Proc Natl Acad Sci U S A 105:3927-32, 2008.

n             Wu, CC, Chin YL, Chen CN, Chien S, Chen YC, Chien CC, Chiu JJ*, Yen BL*. Synergism of biochemical and mechanical stimulation in the differentiation of non-endothelial progenitor cells into endothelial cells J Biomech 41:813-21, 2008.

n             Lo SW, Chen TH, Lo LW, Chiu JJ. Design and construction of a hemodynamic simulator for studying vascular endothelial responses to hemodynamic forces. Biomed Eng: Applications, Basis and Communications 20:95-105, 2008.

n             Chiu JJ*, Usami S, Chien S. Vascular endothelial responses to disturbed flow: pathogenic implications for atherosclerosis. Bioengineering in Cell and Tissue Research (Eds: Gerhard Artmann, Shu Chien), Springer, 2008.

n             Chiu JJ*, Chen LJ, Lee CI, Lee PL, Tasi MC, Lee DY, Usami S, Chien S. Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress. BLOOD 110, 519-528, 2007.

n             Lin CW, Chen LJ, Lee PL, Lee CI, Lin JC, Chiu JJ*. The inhibition of TNF-a-induced E-selectin expression in endothelial cells via the JNK/NF-kB pathways by highly N-acetylated chitooligosaccharides. Biomaterials 28, 1355-1366, 2007.

n             Wu CC, Li YS, Haga JH, Kaunas R, Chiu JJ, Su FC, Usami S, Chien S. Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry. Proc Natl Acad Sci U S A 104, 1254-9, 2007.

n             Chen CN, Li JY, Yeh YT, Lee PL, Usami S, Chien S, Chiu JJ*. Synergistic roles of platelet-derived growth factor-BB and interleukin -1 b i n phenotypic modulation of human aortic smooth muscle cells. Proc Natl Acad Sci U S A 103, 2665-2670, 2006.

n             Chen CN, Chang SF, Lee PL, Chang K, Chen LJ, Usami S, Chien S, Chiu JJ*. Neutrophils, lymphocytes, and monocytes show differential behaviors of transendothelial and subendothelial migrations under co-culture with smooth muscle cells and disturbed flow. BLOOD 107, 1933-1942, 2006.