学术信息
Critical Role of ATF4 in the Anabolic Actions of PTH in Bone
发布日期：2008-05-04
生理与病理生理学系及糖尿病中心学术活动
题目：Critical Role of ATF4 in the Anabolic Actions of PTH in Bone
讲演人：Guozhi Xiao, M.D., Ph.D.
Assistant Professor
Division of Hematology/Oncology
University of Pittsburgh School of Medicine
时间：2008-5-7（Wed）10:00am
地点：生理楼三层会议室
GRADUATE: 1988 Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, M.S. Biochemistry & Molecular Biology 1994 Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Ph.D. Biochemistry & Molecular Biology POSTGRADUATE: 1994-1995, Neurobiology, Mental Health Research Institute, University of Michigan Medical School, Mentor: Dr. Daniel Goodman 1995-1998, Department of Periodontics/Prevention/Geriatrics, University of Michigan Dental School, Mentor: Dr. Renny T. Franceschi APPOINTMENTS AND POSITIONS: 1988-1991 Department of Biochemistry & Molecular Biology, Assistant Professor Health Science Center, Peking University 1998-2004 Department of Periodontics/Oral Medicine, Research Investigator University of Michigan School of Dentistry, Ann Arbor, MI 2004-2005 Department of Periodontics//Oral Medicine, Research Assistant Professor University of Michigan School of Dentistry, Ann Arbor, MI 2005 to Present Department of Medicine, Division of Hematology/Oncology, Assistant Professor University of Pittsburgh School of Medicine, Pittsburgh, PA Selected publications: Jiang D, Franceschi RT, Boules H, and Xiao G*. Parathyroid Hormone Induction of the Osteocalcin Gene: requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple signaling pathways. J Biol Chem. 2004; 279:5329-5337. Xiao G*, Jiang D, Ge C, Zhao Z, Boules H, Phimphilai M, Yang X, Karsenty G, and Boules H, Franceschi RT. Cooperative interactions between ATF4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem. 2005; 280:30689-30696. Singha UK, Jiang Y. Yu S, Luo M, Lu Y, Zhang J, Xiao G*. Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells. J Cell Biochem. 2007; 103(2): 434-46. Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G*. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology, 2008; 149(4): 1960-8. Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G*. General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2. J Biol Chem. 2008; 283(9):5542-53.
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