Education

CANCER RESEARCH, SUNNYBROOK HEALTH SCIENCE CENTER,

UNIVERSITY OF TORONTO, CANADA

Postdoctoral fellow, June, 1998 to June 2000

Research associate & Supervisor of Transgenic Core Facility, June 2000- August 2001

DIVISION OF CARDIOVASCULAR RESEARCH, THE HOSPITAL FOR SICK CHILDREN, TORONTO

Postdoctoral fellow, November, 1995- June 1998

CENTER FOR HUMAN GENETICS, UNIVERSITY OF LEUVEN, BELGIUM

Postdoctoral fellow, June 1995-Oct. 1995.

CENTRE FOR HUMAN GENETICS, UNIVERSITY OF LEUVEN, BELGIUM

Ph. D. of Medical Science , May, 1995

NANJING RAILWAY MEDICAL UNIVERSITY, NANJING, CHINA

Bachelor of Medicine, January, 1982

FACULTY OF CARDIOLOGY, PEKING UNION MEDICAL UNIVERSITY, BEIJING, CHINA

Master of Medicine, July, 1987

Employment / Experience

HHMI, Janelia Farm Research Campus

            Director, Gene Targeting & Transgenic Facility,  October 1, 2007

UNIVERSITY OF CONNECTICUT HEALTH CENTER

Assistant Professor, Department of Genetics & Developmental Biology

Director, Gene Targeting & Transgenic Facility, May 1, 2002 – September 30, 2007

THE JOHN P ROBARTS RESEARCH INSTITUTE,

UNIVERSITY OF WESTERN ONTARIO, CANADA

Manager, Transgenic Facility & ES cell Facility, September 2001 to April 2002.

Selected publication

1.    Hao Z, Guo C, Jiang X, Krueger S, Pietri T, Dufour S, Cone RE and O’Rourke J: New Transgenic evidence for a system of sympathetic axons able to express tissue plasminogen  activator (t-PA)within arterial/arteriolar walls. Blood. 2006 108(1):200-202.

2.    Li X, Liu P, Liu W, Maye P, Zhang J, Zhang Y, Hurley M, Guo C, Boskey A, Sun L, Harris SE, Rowe DW, Ke HZ. Wu D: Dkk2 has a role in terminal osteoblast  differentiation  and mineralized matrix formation. Nat Genet. 2005 Sep;37(9):945-52.

3.    Guo C, Yang WY and Lobe CG: A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis 2002 Jan 32 (1):8-18.

4.    Guo C, Ju H, Leung D, Massaeli H, Shi M, Rabinovitch M.: A novel vascular smooth muscle chymase is upregulated in hypertensive rats. J Clin Invest 2001 Mar;107(6):703-15.

5.    Guo C, B.Van Damme, Y. Vanrenterghem, K. Devriend, J.J. Cassiman, P.Marynen: Severe Alport phenotype in a woman with two missense mutations in the same COL4A5 gene and preponderant inactivation of the X chromosome carrying the normal allele. J Clin Invest 95(4):1832-1837, 1995.

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