学术信息
Diabetes, Aging, and Longevity: The Insulin Paradox
发布日期：2007-10-08
生理与病理生理学系及糖尿病中心学术活动
题目：Diabetes, Aging, and Longevity: The Insulin Paradox
讲演人：Jeffrey B. Halter, M.D
Professor of Internal Medicine
Chief, Division of Geriatric Medicine
Director, Geriatrics Center and Institute of Gerontology
时间：2007-10-12（Friday），11: 30am
地点：生理楼三层会议室
Dr. Halter's laboratory studies neuroendocrine regulation of metabolism in aging and in type 2 diabetes mellitus. Projects address potential mechanisms that contribute to hyperglycemia observed in elderly people and in patients with type 2 diabetes mellitus. These studies involve defining quantitative aspects of pancreatic beta cell function and insulin action in young controls and elderly patients with normal glucose metabolism, impaired carbohydrate tolerance, or overt type 2 diabetes. Related studies are investigating pancreatic islet adaptation to insulin resistance in human aging and hypertension by studying pancreatic beta cell function in relationship to measurement of insulin resistance. Selected Publications: (more than 200 articles) Chang, A.M., Jakobsen, G., Sturis, J., Smith, M.J., Bloem, C.J., Lyness, W., An, B., Galecki, A., and Halter, J.B.: The GLP-1 derivative NN2211 restores beta cell sensitivity to glucose in type 2 diabetic patients after a single dose. Diabetes 2003;52:1786-1791. Chang, A.M., Smith, M.J., Bloem, C.J., Galecki, A.T., and Halter, J.B.: Effect of lowering postprandial hyperglycemia on insulin secretion in older people with impaired glucose tolerance. Am. J. Physiol. (Endo. Metabol.) 2004;287:E906-E911. Schigelone, A.S., Fitzgerald, J.T., Halter, J.B.: Attitude theory revisited: A quantitative analysis of medical students’ interest in geriatrics. Annals of Behavioral Science and Medical Education. 2005; 11:78-84. Chang, A.M., Smith, M.J., Bloem, C.J., Galecki, A.T., Halter, J.B., and Supiano, M.A:. Limitation of the homeostasis model assessment to predict insulin resistance and beta-cell dysfunction in older people. J. Clin. Endocrinol. Metab. 2006; 91:629-634. Boyd, C.M., Weiss, C.O., Halter, J., Han, K.C., Ershler, W.B., and Fried, L.P.: Framework for evaluating disease severity measures in older adults with comorbidity. J. Gerontology: Medical Sciences. 2007; 62A(3):286-295.
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