学术信息
Stem Cells and Arteriosclerosis
发布日期：2008-03-25
生理与病理生理学系及糖尿病中心学术活动
题目：Stem Cells and Arteriosclerosis
讲演人：徐清波教授
BHF John Parker Chair of Cardiovascular Sciences,Cardiovascular Division, Kings College London,
时间：2008-3-28（Friday）
地点：生理楼三层会议室
After training as a medical student at Qingdao Medical School in China, Qingbo Xu came to Europe in 1988, to join Professor Georg Wick’s group at the Institute for Experimental Pathology (Innsbruck, Austria). Two years spent at the Laboratory of Biological Chemistry (NIH, USA) provided him with further expertise, and he came back to Europe and set up his own research group in London. From the very beginning, Xu adopted an approach based on integration of techniques, aiming to exploit the available tools and obtain a better understanding of pathological phenomena related to atherosclerosis. Today, Professor Xu, John Parker Chair of Vascular Biology at King’s College London, University of London, is a renowned scientist with more than 100 papers; numerous visiting scientists ask to train in his laboratory and observe his scientific research. Many of Xu’s scientific interests focus on stem and progenitor cells. One of his studies examined the events occurring at the site of organ transplantation (“allografts”), where endothelial cells were damaged by immune reactions but subsequently regenerated. He showed that the endothelial cells invading the allograft did not come from the donor, as previously believed, but from the recipient’s blood. His group also recently found that abundant stem/progenitor cells exist in the arterial adventitia - the outermost connective tissue of vessels, which is known to contribute to pathological events such as restenosis (the re-narrowing of a coronary artery after it has been treated with angioplasty or stents) and atherosclerosis. Proving, as he did, that progenitor cells in the adventitia can differentiate into smooth muscle cells, which contribute to lesion formation in vein grafts, could influence tissue engineering approaches to therapy. Selected publications: Mayr M, Yusuf S, Weir G, Chung Y-L, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza A, Fredericks S, Stubbs M, Griffiths JR, Jahangiri M, Xu Q, Camm JA. Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol. 2007; 51 : 585-594 Yin X, Mayr M, Xiao Q, Wang W, Xu Q. Proteomic Analysis Reveals Higher Demand for Antioxidant Protection in Embryonic Stem Cell-derived Smooth Muscle Cells. Proteomics. 2006; 6 : 6437-6446. Mayr M, Chung YL, Mayr U, Yin X, Ly L, Troy H, Fredericks S, Hu Y, Griffiths JR, Xu Q. Proteomic and Metabolomic Analyses of Atherosclerotic Vessels From Apolipoprotein E-Deficient Mice Reveal Alterations in Inflammation, Oxidative Stress, and Energy Metabolism. Arterioscler. Thromb. Vasc. Biol. 2005; 25 : 2135-2142 Mayr M, Siow R, Chung YL, Mayr U, Griffiths JR, Xu Q. Proteomic and metabolomic analysis of vascular smooth muscle cells: role of PKCdelta. Circ Res. 2004; 94 : e87-96 Hu Y, Zhang Z, Tosney E, Afzal AR, Davison F, Metzler B and Xu Q. Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in apoE-deficeint mice. J Clin Invest. 2004; 113 : 1258-1265.
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